Antibiotic Dry Powder Injection / Cefazolin Sodium Injection
Product : Cefazolin Sodium for Injection
Specification : 0.5g, 1.0g
Standard : BP, USP
Packing : 50vials/box
A semisynthetic cephalosporin analog with broad-spectrum antibiotic
action due to inhibition of bacterial cell wall synthesis. It
attains high serum levels and is excreted quickly via the urine.
Mainly used to treat bacterial infections of the skin. It can also
be used to treat moderately severe bacterial infections involving
the lung, bone, joint, stomach, blood, heart valve, and urinary
tract. It is clinically effective against infections caused by
staphylococci and streptococci species of Gram positive bacteria.
May be used for surgical prophylaxis; if required metronidazole may
be added to cover B. fragilis.
Cefazolin (also known as cefazoline or cephazolin) is a
semi-synthetic first generation cephalosporin for parenteral
administration. Cefazolin has broad-spectrum antibiotic action due
to inhibition of bacterial cell wall synthesis. It attains high
serum levels and is excreted quickly via the urine.
Mechanism of action :
In vitro tests demonstrate that the bactericidal action of
cephalosporins results from inhibition of cell wall synthesis. By
binding to specific penicillin-binding proteins (PBPs) located
inside the bacterial cell wall, it inhibits the third and last
stage of bacterial cell wall synthesis. Cell lysis is then mediated
by bacterial cell wall autolytic enzymes such as autolysins.