Benzylpenicillin Sodium Injection , Penicillin G Benzathine
Product : Benzylpenicillin Sodium for Injection
Specification : 0.8mega, 1.0mega, 1.6mega, 2.0mega, 5.0mega, 10mega
Standard : BP,USP,EP
Packing : 50 vials/box
Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used
to treat infections caused by susceptible bacteria. It is a natural
penicillin antibiotic that is administered intravenously or
intramuscularly due to poor oral absorption. Penicillin G may also
be used in some cases as prophylaxis against susceptible organisms.
Natural penicillins are considered the drugs of choice for several
infections caused by susceptible gram positive aerobic organisms,
such as Streptococcus pneumoniae, groups A, B, C and G
streptococci, nonenterococcal group D streptococci, viridans group
streptococci, and non-penicillinase producing staphylococcus.
Aminoglycosides may be added for synergy against group B
streptococcus (S. agalactiae), S. viridans, and Enterococcus
faecalis. The natural penicillins may also be used as first or
second line agents against susceptible gram positive aerobic
bacilli such as Bacillus anthracis, Corynebacterium diphtheriae,
and Erysipelothrix rhusiopathiae. Natural penicillins have limited
activity against gram negative organisms; however, they may be used
in some cases to treat infections caused by Neisseria meningitidis
and Pasteurella. They are not generally used to treat anaerobic
infections. Resistance patterns, susceptibility and treatment
guidelines vary across regions.
For use in the treatment of severe infections caused by penicillin
G-susceptible microorganisms when rapid and high penicillin levels
are required such as in the treatment of septicemia, meningitis,
pericarditis, endocarditis and severe pneumonia.
Penicillin G is a penicillin beta-lactam antibiotic used in the
treatment of bacterial infections caused by susceptible, usually
gram-positive, organisms. The name "penicillin" can either refer to
several variants of penicillin available, or to the group of
antibiotics derived from the penicillins. Penicillin G has in vitro
activity against gram-positive and gram-negative aerobic and
anaerobic bacteria. The bactericidal activity of penicillin G
results from the inhibition of cell wall synthesis and is mediated
through penicillin G binding to penicillin binding proteins (PBPs).
Penicillin G is stable against hydrolysis by a variety of
beta-lactamases, including penicillinases, and cephalosporinases
and extended spectrum beta-lactamases.
Mechanism of action :
By binding to specific penicillin-binding proteins (PBPs) located
inside the bacterial cell wall, penicillin G inhibits the third and
last stage of bacterial cell wall synthesis. Cell lysis is then
mediated by bacterial cell wall autolytic enzymes such as
autolysins; it is possible that penicillin G interferes with an