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Benzylpenicillin Sodium Injection , Penicillin G Benzathine Injection

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Benzylpenicillin Sodium Injection , Penicillin G Benzathine Injection

MOQ : 200, 000 vials
Delivery Time : 45days
Packaging Details : Packing:50 vials/box
Brand Name : Newlystar
Place of Origin : China
Model Number : 0.8mega, 1.0mega, 1.6mega, 2.0mega, 5.0mega, 10mega
Certification : GMP
Price : Negotiation
Supply Ability : 500, 000 vials per day
Product : Benzylpenicillin Sodium for Injection Penicillin G
Specification : 0.8mega, 1.0mega, 1.6mega, 2.0mega, 5.0mega, 10mega
Standard : BP,USP,EP
Packing : 50 vials/box
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Benzylpenicillin Sodium Injection , Penicillin G Benzathine Injection


Product : Benzylpenicillin Sodium for Injection

Specification : 0.8mega, 1.0mega, 1.6mega, 2.0mega, 5.0mega, 10mega

Standard : BP,USP,EP

Packing : 50 vials/box


Description :

Benzylpenicillin (Penicillin G) is narrow spectrum antibiotic used to treat infections caused by susceptible bacteria. It is a natural penicillin antibiotic that is administered intravenously or intramuscularly due to poor oral absorption. Penicillin G may also be used in some cases as prophylaxis against susceptible organisms. Natural penicillins are considered the drugs of choice for several infections caused by susceptible gram positive aerobic organisms, such as Streptococcus pneumoniae, groups A, B, C and G streptococci, nonenterococcal group D streptococci, viridans group streptococci, and non-penicillinase producing staphylococcus. Aminoglycosides may be added for synergy against group B streptococcus (S. agalactiae), S. viridans, and Enterococcus faecalis. The natural penicillins may also be used as first or second line agents against susceptible gram positive aerobic bacilli such as Bacillus anthracis, Corynebacterium diphtheriae, and Erysipelothrix rhusiopathiae. Natural penicillins have limited activity against gram negative organisms; however, they may be used in some cases to treat infections caused by Neisseria meningitidis and Pasteurella. They are not generally used to treat anaerobic infections. Resistance patterns, susceptibility and treatment guidelines vary across regions.


Indication :

For use in the treatment of severe infections caused by penicillin G-susceptible microorganisms when rapid and high penicillin levels are required such as in the treatment of septicemia, meningitis, pericarditis, endocarditis and severe pneumonia.


Pharmacodynamics :

Penicillin G is a penicillin beta-lactam antibiotic used in the treatment of bacterial infections caused by susceptible, usually gram-positive, organisms. The name "penicillin" can either refer to several variants of penicillin available, or to the group of antibiotics derived from the penicillins. Penicillin G has in vitro activity against gram-positive and gram-negative aerobic and anaerobic bacteria. The bactericidal activity of penicillin G results from the inhibition of cell wall synthesis and is mediated through penicillin G binding to penicillin binding proteins (PBPs). Penicillin G is stable against hydrolysis by a variety of beta-lactamases, including penicillinases, and cephalosporinases and extended spectrum beta-lactamases.


Mechanism of action :

By binding to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, penicillin G inhibits the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that penicillin G interferes with an autolysin inhibitor.


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