Sign In | Join Free | My vivirlatino.com
vivirlatino.com
Newlystar (Ningbo) Medtech Co.,Ltd.
Newlystar Medtech, your professional one-stop China Souring Partner!
Home > Small Volume Parenteral >

Granulocyte Colony Stimulating Factor G-CSF / rhG-CSF Filgrastim Injection

Newlystar (Ningbo) Medtech Co.,Ltd.
Trust Seal
Verified Supplier
Credit Check
Supplier Assessment

Granulocyte Colony Stimulating Factor G-CSF / rhG-CSF Filgrastim Injection

MOQ : 10000 vials
Payment Terms : L/C, T/T
Delivery Time : 45days
Packaging Details : 10vials/box
Brand Name : Newlystar
Place of Origin : China
Model Number : 75/100/125/150/200/300mcg
Certification : GMP
Price : Negotiation
Supply Ability : 50, 000 vials per day
Product : Filgrastim Recombinant Human Granulocyte Colony-Stimulating Factor Injection G-CSF rhG-CSF
Specification : 75/100/125/150/200/300mcg
Standard : In - house
Packing : 10vials/box
Contact Now

Granulocyte Colony Stimulating Factor G-CSF / rhG-CSF Filgrastim Injection


Product : Filgrastim Recombinant Human Granulocyte Colony-Stimulating Factor Injection G-CSF rhG-CSF

Specification : 75/100/125/150/200/300mcg

Standard : In - house

Packing : 10vials/box


Description :

Filgrastim is a recombinant, non-pegylated human granulocyte colony stimulating factor (G-CSF) analogue manufactured by recombinant DNA technology using a strain of E. coli. It is marketed as the brand name Neupogen by Amgen. Chemically, it consists of 175 amino acid residues. The protein has an amino acid sequence that is identical to the natural sequence predicted from human DNA sequence analysis, except for the addition of an N-terminal methionine necessary for expression in E coli.


Indication

Filgrastim is used in patients with acute myeloid leukemia receiving induction or consolidation chemotherapy. It is also used in cancer patients receiving bone marrow transplant. In general, filgrastim increases neutrophil counts in order to decrease the risk of infection or duration of neutropenia in the aforementioned patient populations. Infection and neutropenia are adverse events associated with chemotherapy. Furthermore, filgrastim is also indicated for patients with severe chronic neutropenia. It mobilizes hematopoietic progenitor cells into the peripheral blood for collection by leukapheresis to allow for a more rapid engraftment. Tbo-filgrastim has a narrower indication profile than Neupogen - it is a leukocyte growth factor indicated for the reduction in the duration of severe neutropenia in patients with non-myeloid malignancies.


Pharmacodynamics

Used in the treatment of chemotherapy-induced neutropenia by enhancing the production of neutrophils. Filgrastim acts on hematopoietic cells by binding to specific cell surface receptors thereby stimulating proliferation, differentiation, commitment, and end cell functional activation. When tbo-filgrastim is administered to cancer patients, it took 3-5 days to reach maximum absolute neutrophil count (ANC). Levels of neutrophils returned to baseline by 21 days following completion of chemotherapy. In the healthy volunteer trials, doubling the tbo-filgrastim subcutaneous dose from 5 to 10 mcg/kg resulted in a 16-19% increase in the ANCmax and a 33-36% increase in the area under the effect curve for ANC.


Mechanism of action

Filgrastim binds to the G-CSF receptor and stimulates the production of neutrophils in the bone marrow. As a G-CSF analog, it controls proliferation of committed progenitor cells and influences their maturation into mature neutrophils. Filgrastim also stimulates the release of neutrophils from bone marrow storage pools and reduces their maturation time. Filgrastim acts to increase the phagocytic activity of mature neutrophils. In patients receiving cytotoxic chemotherapy, Filgrastim can accelerate neutrophil recovery, leading to a reduction in duration of the neutropenic phase.


Product Tags:

Small Volume Injection

      
China Customized Inflatable Bumper Ball Game Bubble Adult Grass CE supplier

Granulocyte Colony Stimulating Factor G-CSF / rhG-CSF Filgrastim Injection Images

Inquiry Cart 0
Send your message to this supplier
 
From:
Enter your email please.
To: Newlystar (Ningbo) Medtech Co.,Ltd.
Subject:
Message:
Characters Remaining: (0/3000)
 
Inquiry Cart 0