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Pre Filled Syringe Small Volume Parenteral Nadroparin Calcium Injection

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Pre Filled Syringe Small Volume Parenteral Nadroparin Calcium Injection

MOQ : 5000boxes
Payment Terms : L/C, T/T
Delivery Time : 45days
Packaging Details : 2’s/box
Brand Name : Newlystar
Place of Origin : China
Model Number : PFS, 0.3 ml/2850IU, 0.6 ml/5700IU, 0.8 ml/7600IU
Certification : GMP
Price : Negotiation
Supply Ability : 20, 000 boxes per day
Product : Nadroparin Calcium Injection Pre-filled Syringe
Specification : PFS, 0.3 ml/2850IU, 0.6 ml/5700IU, 0.8 ml/7600IU
Standard : In - house
Packing : 2’s/box
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Pre Filled Syringe Small Volume Parenteral Nadroparin Calcium Injection


Product : Nadroparin Calcium Injection Pre-filled Syringe

Specification : PFS, 0.3 ml/2850IU, 0.6 ml/5700IU, 0.8 ml/7600IU

Standard : In - house

Packing : 2’s/box


Description :

Nadroparin is a low molecular weight heparin (LMWH) which, when bound to antithrombin III (ATIII), accelerates the inactivation of factor II and factor Xa. Nadroparin halts the coagulation pathway by inhibiting the activation of thrombin (factor IIa) by factor Xa. The amplification of the fibrin clotting cascade is stopped once factors Xa and IIa are inactivated. It is derived from porcine sources and has a mean molecular size of 5000 daltons. Low molecular weight heparins are less effective at inactivating factor IIa due to their shorter length compared to unfractionated heparin.


Indication

Nadroparin is used for prophylaxis of thromboembolic disorders and general surgery in orthopedic surgery, treatment of deep vein thrombosis, prevention of clotting during hemodialysis and treatment of unstable angina and non-Q wave myocardial infarction


Pharmacodynamics

Nadroparin is a low molecular weight heparin that is composed of a heterogeneous mixture of sulfated polysaccaride glycosaminoglycan chains. Th mean molecular weight is approximately 4300 daltons. The ratio of anti-Xa activity to anti-IIa is 3.5:1 whereas it is about 1:1 for heparin. Its use should be avoided in patients with a creatinine clearance less than 40mL/min. In these patients, unfractionated heparin should only be used. As for monitoring, active partial thromboplastin time (aPTT) will only increase at high doses of low molecular weight heparins (LMWH). Therefore, monitoring aPTT is not recommended. However, anti-Xa activity can be measured to monitor the efficacy of the LMWH.


Mechanism of action

The mechanism of action for nadroparin is similar to all other LMWHs. Like all LMWHs, nadroparin has a pentasaccharide sequence which binds to ATIII, which potentiates the action of ATIII. This complex greatly accelerates the inactivation of factor Xa and factor IIa. As a result, the coagulation cascade is inhibited.


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